2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-105415
    U 92032
    		Inhibitor
    U 92032 is a T-type Ca2+ channel antagonist. U 92032 inhibits Na+ channels. U-92032 inhibits thalamic oscillations. U 92032 can be used in the research of neurological diseases.
    U 92032
  • HY-N11723
    Catenarin
    		Inhibitor
    Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].
    Catenarin
  • HY-N15737
    Fukinolic acid
    		Inhibitor
    Fukinolic acid is a benzyltartaric acid ester, is a vasodilator with antiviral activity against enterovirus A71 (EV-A71) replication. Fukinolic acid is a receptor-operated Ca2+ channels (ROC) inhibitor, suppressing extracellular Ca2+ influx through ROC activated by Norepinephrine (HY-13715) without affecting voltage-dependent Ca2+ channels.
    Fukinolic acid
  • HY-159090
    AT1R antagonist 3
    		Inhibitor
    AT1R antagonist 3 (Compound 1) is an antagonist for angiotensin II type 1 receptor (AT1R) and an inhibitor for calcium channel type-L CaV1.2 (IC50=0.57 μM). AT1R antagonist 3 exhibits vasodilation efficacy in solated rat aorta (10 μM, 88.7%) and antihypertensive efficacy in rat models.
    AT1R antagonist 3
  • HY-N7395B
    Cyclic ADP-​ribose diammonium
    		Activator
    Cyclic ADP-ribose diammonium (cADPR diammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by an ADP-ribosyl cyclase. Cyclic ADP-ribose diammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels.
    Cyclic ADP-​ribose diammonium
  • HY-19409
    AJG049
    		Antagonist
    AJG049 is a novel antagonist of the Ca2+ channel with an IC50 value of 79 nM. AJG049 can be used to reduce the contraction of intestinal smooth muscle.
    AJG049
  • HY-Z15823
    (R)-Verapamil
    		Inhibitor 98.97%
    (R)-Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil (HY-14275). (R)-Verapamil has a relatively low affinity for L-type calcium channels (Cav1.2) (IC50 > 300 μM), and its IC50 for sodium channels (sodium channel) is 3.19 μM. (R)-Verapamil exhibits SSTR2 agonistic activity, with an EC50 of 1.3 μM. (R)-Verapamil significantly downregulates the expression of TXNIP protein in diabetic mouse models and significantly inhibits β-cell apoptosis (apoptosis), effectively controlling blood sugar. (R)-Verapamil can be used as a PET tracer for the function of P-glycoprotein (P-gp).
    (R)-Verapamil
  • HY-B0380S1
    Trimebutine-d5 fumarate
    		Inhibitor
    Trimebutine-d5 fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
    Trimebutine-d<sub>5</sub> fumarate
  • HY-101390A
    (-)-Niguldipine hydrochloride
    		Antagonist
    (-)-Niguldipine ((R)-Niguldipine) hydrochloride is a calcium channel antagonist. (-)-Niguldipine hydrochloride exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (-)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55). (-)-Niguldipine hydrochloride can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias.
    (-)-Niguldipine hydrochloride
  • HY-W012399R
    2,5-Di-tert-butylhydroquinone (Standard)
    		Inhibitor
    2,5-Di-tert-butylhydroquinone (Standard) is the analytical standard of 2,5-Di-tert-butylhydroquinone. This product is intended for research and analytical applications. 2,5-Di-tert-butylhydroquinone (BHQ) (Compound 2), an indirect food additive, is a Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor with an IC50 of 400 nM. 2,5-Di-tert-butylhydroquinone disrupts the gating function of the residue Glu309 which prevents Ca2+ from reaching their binding site. 2,5-Di-tert-butylhydroquinone regulates the activity of 5-lipoxygenase and COX-2 (IC50: 1.8 and 14.1 μM for 5-LO and COX-2, respectively).
    2,5-Di-tert-butylhydroquinone (Standard)
  • HY-175408
    Hepoxilin A3 methyl ester
    Hepoxilin A3 methyl ester is the ester form of HxA3. Hepoxilin A3 methyl ester causes a receptor-induced rise in intracellular calcium through the release from intracellular stores in suspended human neutrophils.
    Hepoxilin A3 methyl ester
  • HY-113643
    Levemopamil hydrochloride
    		Inhibitor
    Levemopamil hydrochloride is a blood-brain barrier penetrable calcium channel blocker and a 5-HT2 antagonist. Levemopamil hydrochloride can be used for temporary occlusion and neurological disease research.
    Levemopamil hydrochloride
  • HY-106761
    Oxodipine
    		Antagonist
    Oxodipine, a dihydropyridine-type calcium antagonist, inhibits KCl-induced aortic contraction in rabbits and reduces cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduces L-type Ca currents (I) with an IC50 of 0.24 μM, and against T-type Ca currents (I) with an IC50 of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs.
    Oxodipine
  • HY-B0480R
    Brompheniramine maleate (Standard)
    		Inhibitor
    Brompheniramine (maleate) (Standard) is the analytical standard of Brompheniramine (maleate). This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research.
    Brompheniramine maleate (Standard)
  • HY-129088
    HUP30
    		Inhibitor 99.68%
    HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K+ channels, and blocks extracellular Ca2+ influx.
    HUP30
  • HY-17436S4
    Clevidipine-15N,d10
    		Antagonist
    Clevidipine-15N,d10 is 15N and deuterated labeled Clevidipine (HY-17436). Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H)=-40 mV ).
    Clevidipine-<sup>15</sup>N,d<sub>10</sub>
  • HY-110312
    JTV-519 fumarate
    JTV-519 fumarate (K201 fumarate) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. JTV-519 fumarate is a cardioprotective agent with antiarrhythmic effects.
    JTV-519 fumarate
  • HY-105271
    S-312-d
    		Antagonist
    S-312-d (S-(+)-S-312-d) is a calcium channel blocker with the activity of protecting the kidney from ischemic acute renal failure. S-312-d (0.01-0.1mg/kg b.wt. iv) administered before ischemia has a dose-dependent protective effect on ischemia-induced renal damage, improves the survival rate of ischemic rats, and reduces renal cortical edema and the increase in renal tissue calcium content.
    S-312-d
  • HY-P3565
    Sarafotoxin S6d
    Sarafotoxin S6d (STX-b) is a polypeptide toxin isolated from the venom of the Israeli sand boa constrictor. Sarafotoxin S6d induces multiple electrocardiogram (ECG) changes including myocardial ischemia and hyperkalemia. Sarafotoxin S6d induces strong extracellular calcium-dependent vasoconstriction in rat aorta and exhibits positive inotropic effects in rat atria. Sarafotoxin S6d can be used in the study of cardiovascular diseases.
    Sarafotoxin S6d
  • HY-19043
    RS-93522
    		Antagonist
    RS-93522 (RS-93522-004) is a compound with calcium channel antagonist activity that is rapidly absorbed and has high bioavailability via nasal administration.
    RS-93522
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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